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IEEE Trans Biomed Circuits Syst. 2009 Dec;3(6):424-31. doi: 10.1109/TBCAS.2009.2031329. Epub 2009 Oct 30.

Optoelectronic tweezers as a tool for parallel single-cell manipulation and stimulation.

Abstract

Optoelectronic tweezers (OET) is a promising approach for the parallel manipulation of single cells for a variety of biological applications. By combining the manipulation capabilities of OET with other relevant biological techniques (such as cell lysis and electroporation), one can realize a true parallel, single-cell diagnostic and stimulation tool. Here, we demonstrate the utility of the OET device by integrating it onto single-chip systems capable of performing in-situ, electrode-based electroporation/lysis, individual cell, light-induced lysis, and light-induced electroporation.

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