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Nat Neurosci. 2010 Aug;13(8):917-9. doi: 10.1038/nn.2579. Epub 2010 Jun 13.

Neural dynamics of in vitro cortical networks reflects experienced temporal patterns.

Author information

1
Champalimaud Neuroscience Programme, Instituto Gulbenkian de Ciencia, Oeiras, Portugal.

Abstract

Learning ultimately relies on changes in the flow of activity in neural microcircuits. The plasticity of neural dynamics is particularly relevant for the processing of temporal information. Chronic stimulation of cultured rat cortical networks revealed experience-dependent plasticity in neural dynamics. We observed changes in the temporal structure of activity that reflected the intervals used during training, suggesting that cortical circuits are inherently capable of temporal processing on short timescales.

PMID:
20543842
PMCID:
PMC2910842
DOI:
10.1038/nn.2579
[Indexed for MEDLINE]
Free PMC Article

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