Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin HIV AIDS. 2010 Jul;5(4):335-43. doi: 10.1097/COH.0b013e32833a0b69.

Antiretroviral drug concentrations in the male and female genital tract: implications for the sexual transmission of HIV.

Author information

1
Department of Sexual Health and HIV Medicine, Directorate of Infection, Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust, University of Birmingham, Birmingham, UK. steve.taylor@heartofengland.nhs.uk

Abstract

PURPOSE OF REVIEW:

To summarize the recent literature (2008-2010) on antiretroviral (ARV) drug disposition into the male and female genital tract.

RECENT FINDINGS:

Recent studies have confirmed that penetration of antiretroviral agents into the male and female genital tracts are both drug and sex specific. Concentrations achieved vary considerably depending on the class of drug studied, the sampling techniques used and the times samples are obtained.

SUMMARY:

There appear to be several patterns of drug penetration into the male and female genital tract. In addition there appear to be different patterns of genital shedding under the influence of antiretroviral therapy. What effect these factors will have on the sexual transmission of HIV or the evolution and transmission of resistant HIV remains to be seen.

PMID:
20543610
DOI:
10.1097/COH.0b013e32833a0b69
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins - Ovid Insights
    Loading ...
    Support Center