Format

Send to

Choose Destination
J Pediatr. 2010 Nov;157(5):720-5.e1-2. doi: 10.1016/j.jpeds.2010.04.065. Epub 2010 Jun 14.

Seizures in extremely low birth weight infants are associated with adverse outcome.

Collaborators (202)

Jobe AH, Caplan MS, Fanaroff AA, Wilson-Costello DE, Newman NS, Siner BS, Schibler K, Donovan EF, Steichen JJ, Yolton K, Bridges K, Alexander B, Gratton TL, Grisby C, Mersmann MW, Mincey HL, Hessling J, Goldberg RN, Goldstein RF, Cotten CM, Fisher KA, Gustafson KE, Lohmeyer MB, Carlton DP, Adams-Chapman I, Black L, Blackwelder AM, Carter S, Dinkins E, Hale EC, Miller J, Mulligan LaRossa M, Seabrook I, Smikle GV, Wright LL, McClure EM, Archer S, Poindexter BB, Lemons JA, Cook AB, Dusick AM, Herron DE, Miller LC, Minnich HM, Richard L, Wilson LD, Hamer F, Poole WK, Hastings BK, McClure EM, Cunningham M, O'Donnell Auman J, Newman JE, Huitema CP, Zaterka-Baxter KM, Stevenson DK, Adams MM, Ball MB, Baran JM, Brudos GK, DeBattista AM, Sivakumar D, St John NH, Carlo WA, Peralta-Carcelen M, Soong A, Collins MV, Cosby SS, Bailey KJ, Biasini FJ, Chopko SA, Moses MB, Nelson KG, Phillips VA, Preskitt J, Rector RV, Whitley S, Finer NN, Wozniak PR, Rasmussen MR, Vaucher YE, Arnell K, Demetrio C, Henderson C, Rich W, Barbieri-Welge R, Ben-Tall A, Fuller MG, Ito E, Lukasik M, Pontillo D, Posin D, Runyan C, Wilkes J, Duara S, Bauer CR, Everett-Thomas R, Calejo M, Diaz AN, Frade Eguaras SM, Gideon Y, Hamlin-Smith K, Hiriart-Fajardo S, Jean-Gilles L, Londono A, Mathews EO, Worth AM, Stroerger A, Watterberg KL, Papile L, Fuller J, Lacy CB, Long DV, Lowe J, Montman R, Rohr J, Phelps DL, Myers GJ, Reubens LJ, Burnell E, Johnson JB, Hust D, Jensen RL, Kushner E, Merzbach J, Yost K, Korones SB, Bada HS, Hudson T, Williams M, Yolton K, Sánchez PJ, Rosenfeld CR, Salhab WA, Broyles RS, Heyne RJ, Adams SS, Dooley C, Hensley G, Heyne E, Hickman JF, Madden LA, Madison S, Miller NA, Morgan JS, Guzman A, Boatman CT, Kennedy KA, Tyson JE, Bradt PJ, Evans PW, Akpa EG, Alaniz N, Cluff PA, Dieterich S, Franco CI, Lis AE, Major-Kincade T, McDavid GE, Morris BH, Simmons MC, Tate PP, Reddoch S, Whitely LL, Wright S, O'Shea TM, Dillard RG, Peters NJ, Allred DE, Goldstein DJ, Jackson BG, Peterson C, Waldrep EL, Morris MW, Hounshell GW, Shankaran S, Delaney-Black V, Johnson YR, Bara R, Muran G, Kennedy D, Goldston L, Oh W, Vohr BR, Stephens BE, Hensman AM, Alksninis B, Cashore B, Leach TM, Leonard MR, Mehta K, Noel L, Ventura S, Watson VE, Ehrenkranz RA, Gettner P, Konstantino M, Poulsen J, Taft J, Close N, Romano E, Williams J.

Author information

1
Division of Neonatal-Developmental Medicine, Stanford University, Stanford, CA, USA.

Abstract

OBJECTIVE:

To examine risk factors for neonatal clinical seizures and to determine the independent association with death or neurodevelopmental impairment (NDI) in extremely low birth weight (ELBW) infants.

STUDY DESIGN:

A total of 6499 ELBW infants (401-1000 g) surviving to 36 weeks postmenstrual age (PMA) were included in this retrospective study. Unadjusted comparisons were performed between infants with (n = 414) and without (n = 6085) clinical seizures during the initial hospitalization. Using multivariate logistic regression modeling, we examined the independent association of seizures with late death (after 36 weeks PMA) or NDI after controlling for multiple demographic, perinatal, and neonatal variables.

RESULTS:

Infants with clinical seizures had a greater proportion of neonatal morbidities associated with poor outcome, including severe intraventricular hemorrhage, sepsis, meningitis, and cystic periventricular leukomalacia (all P < .01). Survivors were more likely to have NDI or moderate-severe cerebral palsy at 18 to 22 months corrected age (both P < .01). After adjusting for multiple confounders, clinical seizures remained significantly associated with late death or NDI (odds ratio, 3.15; 95% CI, 2.37-4.19).

CONCLUSION:

ELBW infants with clinical seizures are at increased risk for adverse neurodevelopmental outcome, independent of multiple confounding factors.

PMID:
20542294
PMCID:
PMC2939969
DOI:
10.1016/j.jpeds.2010.04.065
[Indexed for MEDLINE]
Free PMC Article

Publication type, MeSH terms, Grant support

Publication type

MeSH terms

Grant support

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center