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Int J Gynaecol Obstet. 2010 Oct;111(1):37-40. doi: 10.1016/j.ijgo.2010.04.028. Epub 2010 Jun 14.

Metformin compared with glyburide for the management of gestational diabetes.

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Department of Obstetrics, University of the Region of Joinville (UNIVILLE), Joinville, Brazil.



To assess blood glucose control and neonatal outcomes when women with gestational diabetes mellitus (GDM) were treated with metformin or glyburide.


When an appropriate diet was insufficient to control their blood glucose levels, women with GDM were randomized to a glyburide or a metformin treatment group. If the maximum dose was reached, the assessed drug was replaced by insulin. The primary outcome measures analyzed were maternal glucose levels during pregnancy, birth weight, and neonatal glucose levels.


The only significant difference in outcome between the 2 treatment drugs was that maternal weight gain during pregnancy was less in the metformin (n=40) than in the glyburide group (n=32) (10.3 kg vs 7.6 kg; P=0.02). No differences were found in treatment failure, mean level of fasting or postprandial plasma glucose, rate of participants with glycated hemoglobin, birth weight, rate of large-for-gestational-age newborns, or newborns with hypoglycemia.


The treatment of GDM with metformin or glyburide was found to be equivalent for both women and newborns.

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