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Cell Host Microbe. 2010 Jun 25;7(6):440-51. doi: 10.1016/j.chom.2010.05.009.

Influenza virus evolution, host adaptation, and pandemic formation.

Author information

1
Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Newly emerging or "re-emerging" viral diseases continue to pose significant global public health threats. Prototypic are influenza viruses that are major causes of human respiratory infections and mortality. Influenza viruses can cause zoonotic infections and adapt to humans, leading to sustained transmission and emergence of novel viruses. Mechanisms by which viruses evolve in one host, cause zoonotic infection, and adapt to a new host species remain unelucidated. Here, we review the evolution of influenza A viruses in their reservoir hosts and discuss genetic changes associated with introduction of novel viruses into humans, leading to pandemics and the establishment of seasonal viruses.

PMID:
20542248
PMCID:
PMC2892379
DOI:
10.1016/j.chom.2010.05.009
[Indexed for MEDLINE]
Free PMC Article

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