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Am J Obstet Gynecol. 2010 Aug;203(2):138.e1-8. doi: 10.1016/j.ajog.2010.05.006. Epub 2010 Jun 12.

Factors associated with small head circumference at birth among infants born before the 28th week.

Author information

1
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.

Abstract

OBJECTIVE:

We sought to identify risk factors for congenital microcephaly in extremely low gestational age newborns.

STUDY DESIGN:

Demographic, clinical, and placental characteristics of 1445 infants born before the 28th week were gathered and evaluated for their relationship with congenital microcephaly.

RESULTS:

Almost 10% of newborns (n = 138), rather than the expected 2.2%, had microcephaly defined as a head circumference >2 SD below the median. In multivariable models, microcephaly was associated with nonwhite race, severe intrauterine growth restriction, delivery for preeclampsia, placental infarction, and being female. The risk factors for a head circumference between <1 and >2 SD below the median were similar to those of microcephaly.

CONCLUSION:

Characteristics associated with fetal growth restriction and preeclampsia are among the strongest correlates of microcephaly among children born at extremely low gestational ages. The elevated risk of a small head among nonwhites and females might reflect the lack of appropriate head circumference standards.

PMID:
20541727
PMCID:
PMC2989671
DOI:
10.1016/j.ajog.2010.05.006
[Indexed for MEDLINE]
Free PMC Article

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