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Vaccine. 2010 Jul 19;28(32):5245-53. doi: 10.1016/j.vaccine.2010.05.062. Epub 2010 Jun 10.

The potential value of Clostridium difficile vaccine: an economic computer simulation model.

Author information

1
Applied Modeling, Public Health Computational and Operations Research Group (PHICOR), Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, PA 15213, USA. BYL1@pitt.edu

Abstract

Efforts are currently underway to develop a vaccine against Clostridium difficile infection (CDI). We developed two decision analytic Monte Carlo computer simulation models: (1) an Initial Prevention Model depicting the decision whether to administer C. difficile vaccine to patients at-risk for CDI and (2) a Recurrence Prevention Model depicting the decision whether to administer C. difficile vaccine to prevent CDI recurrence. Our results suggest that a C. difficile vaccine could be cost-effective over a wide range of C. difficile risk, vaccine costs, and vaccine efficacies especially, when being used post-CDI treatment to prevent recurrent disease.

PMID:
20541582
PMCID:
PMC2908196
DOI:
10.1016/j.vaccine.2010.05.062
[Indexed for MEDLINE]
Free PMC Article
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