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Structure. 2010 Jun 9;18(6):657-9. doi: 10.1016/j.str.2010.05.006.

The lighter side of a sweet reaction.

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1
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

Abstract

The unique advantage of neutrons as biological probes is the ability to visualize hydrogen atoms in macromolecules. In this issue, Kovalevsky et al. (2010) solved an ensemble of xylose isomerase structures by neutron crystallography, and the determination of hydrogen atom rearrangements during the catalytic cycle provides insight into the enzyme's mechanism.

PMID:
20541500
DOI:
10.1016/j.str.2010.05.006
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