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Transplant Rev (Orlando). 2010 Jul;24(3):147-59. doi: 10.1016/j.trre.2010.04.002. Epub 2010 Jun 11.

T regulatory cells and transplantation tolerance.

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1
Division of Plastic Surgery, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

Abstract

Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation. The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.

PMID:
20541385
PMCID:
PMC2902703
DOI:
10.1016/j.trre.2010.04.002
[Indexed for MEDLINE]
Free PMC Article
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