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Arterioscler Thromb Vasc Biol. 2010 Sep;30(9):1855-60. doi: 10.1161/ATVBAHA.110.207340. Epub 2010 Jun 10.

Serum gamma-glutamyl transferase and risk of heart failure in the community.

Author information

1
National Heart, Lung, and Blood Institute's Framingham Heart Study, Framingham, MA 01702-5803, USA.

Abstract

OBJECTIVE:

To examine the association of serum gamma-glutamyltransferase (GGT) with incident heart failure.

METHODS AND RESULTS:

We related serum GGT to the incidence of heart failure in 3544 (mean age, 44.5 years; 1833 women and 1711 men) Framingham Study participants who were free of heart failure and myocardial infarction. On follow-up (mean, 23.6 years), 188 participants (77 women) developed new-onset heart failure. In multivariable Cox proportional hazards regression models adjusting for standard risk factors and alcohol consumption as time-varying covariates (updated every 4 years), each SD increase in log-GGT was associated with a 1.39-fold risk of heart failure (95% CI, 1.20 to 1.62). The linearity of the association was confirmed by multivariable-adjusted splines, and the relations remained robust on additional adjustment for hepatic aminotransferases and C-reactive protein. Participants with a serum GGT level at the median or greater had a 1.71-fold risk of heart failure (95% CI, 1.21 to 2.41) compared with individuals with GGT concentrations less than the median. GGT marginally increased the model C-statistic from 0.85 to 0.86 but improved the risk reclassification modestly (net reclassification index, 5.7%; P=0.01).

CONCLUSIONS:

In this prospective study of a large community-based sample, higher serum GGT concentrations within the "normal" range were associated with greater risk of heart failure and incrementally improved prediction of heart failure risk.

PMID:
20539015
PMCID:
PMC2924453
DOI:
10.1161/ATVBAHA.110.207340
[Indexed for MEDLINE]
Free PMC Article

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