Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Cell Biol. 2010 Aug;22(4):535-40. doi: 10.1016/j.ceb.2010.05.007. Epub 2010 Jun 9.

Signaling endosomes: seeing is believing.

Author information

1
International Institute of Molecular and Cell Biology, Laboratory of Cell Biology, 4 Ks. Trojdena Street, 02-109 Warsaw, Poland. miaczynska@iimcb.gov.pl

Abstract

Signaling compartmentalization provides a highly refined mechanism to specify context-dependent cellular responses. Endosomes are an intracellular membrane-bound compartment that mediates the transport of receptor-bound signaling complexes. Owing to the development of high-resolution microscopy-based imaging techniques it has been possible to demonstrate that endosomes are actively engaged in signal reception and emission. Such observations paved the way to functional studies ascribing indispensable roles for endosomes in orchestrating signals that regulate processes such as cell migration and invasion, asymmetric cell division and differentiation, or intercellular communication.

PMID:
20538448
PMCID:
PMC3020151
DOI:
10.1016/j.ceb.2010.05.007
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center