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Psychiatry Res. 2011 Jan 30;185(1-2):290-2. doi: 10.1016/j.psychres.2009.11.026. Epub 2010 May 26.

Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population.

Author information

1
Bio-X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong, University, PR China.

Abstract

In the present work we genotyped three single-nucleotide polymorphisms (SNPs) (rs7301328, rs1805247, and rs1805502) of the GRIN2B gene in a set of 480 unrelated bipolar disorder patients and 480 unrelated genetically matched normal controls in Chinese Han population by either allelic-specific multiplex ligation-detection reaction (AMLR) technology or direct sequencing. Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder.

PMID:
20537720
DOI:
10.1016/j.psychres.2009.11.026
[Indexed for MEDLINE]

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