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Psychiatry Res. 2011 Jan 30;185(1-2):16-9. doi: 10.1016/j.psychres.2009.11.003.

Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population.

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1
Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan. k-chieko@umin.ac.jp

Abstract

To examine the association of PPP3CC (rs10108011 and rs2461491) and EGR3 (rs3750192) single-nucleotide polymorphisms (SNPs) with Japanese schizophrenia, we performed a case-control association study using 337 patients and 369 healthy controls. As a result, by our moderated cohort-size study, PPP3CC and EGR3 are not genetic risk factors for schizophrenia, whereas meta-analysis showed weak association of rs10108011 with schizophrenia in the Japanese population (odds ratio (OR)=1.12, P=0.01).

PMID:
20537399
DOI:
10.1016/j.psychres.2009.11.003
[Indexed for MEDLINE]
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