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Curr Top Med Chem. 2010;10(14):1441-69.

Recent advances in the medicinal chemistry of novel erythromycin-derivatized antibiotics.

Author information

1
Enanta Pharmaceuticals, Inc., Watertown, MA 02472, USA.

Abstract

Development of novel erythromycin-based antibiotics has been one of the most studied topics in the past three decades. Such tremendous efforts have generated a number of beneficiary drugs such as clarithromycin, azithromycin and telithromycin. However, widespread application of antibiotics in clinical practice has triggered an increasing emergence of bacterial resistance. Therefore, discovery of novel macrolide antibiotics to suppress the resistance is urgent for human healthcare. This review focuses on advances in the area since 2004.

PMID:
20536419
DOI:
10.2174/156802610792232042
[Indexed for MEDLINE]

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