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Nature. 2010 Jun 10;465(7299):728-35. doi: 10.1038/nature09231.

Brain function and chromatin plasticity.

Author information

1
Howard Hughes Medical Institute, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA. dulac@fas.harvard.edu

Abstract

The characteristics of epigenetic control, including the potential for long-lasting, stable effects on gene expression that outlive an initial transient signal, could be of singular importance for post-mitotic neurons, which are subject to changes with short- to long-lasting influence on their activity and connectivity. Persistent changes in chromatin structure are thought to contribute to mechanisms of epigenetic inheritance. Recent advances in chromatin biology offer new avenues to investigate regulatory mechanisms underlying long-lasting changes in neurons, with direct implications for the study of brain function, behaviour and diseases.

PMID:
20535202
PMCID:
PMC3075582
DOI:
10.1038/nature09231
[Indexed for MEDLINE]
Free PMC Article

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