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J Clin Endocrinol Metab. 2010 Sep;95(9):E1-8. doi: 10.1210/jc.2010-0482. Epub 2010 Jun 9.

An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol.

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1
Division of Endocrinology, Diabetes, and Metabolism, State University of New York at Buffalo and Kaleida Health, Buffalo, New York 14209, USA.

Abstract

BACKGROUND:

Resveratrol have been shown to exert an antiinflammatory and antiaging effects in vitro and in animal models.

OBJECTIVE:

The objective of the study was to investigate the effect of a Polygonum cuspidatum extract (PCE) containing resveratrol on oxidative and inflammatory stress in normal subjects.

RESEARCH DESIGN AND METHODS:

Two groups (10 each) of normal-weight healthy subjects were randomized to placebo or PCE containing 40 mg resveratrol daily for 6 wk. Fasting blood samples were obtained prior to and after treatment at 1, 3, and 6 wk. Mononuclear cells were prepared for reactive oxygen species generation, RNA isolation, nuclear extract, and total cell homogenate preparation. Indices of oxidative and inflammatory stress, suppressor of cytokine signaling-3, phosphotyrosine phosphatase-1B, jun-N-terminal kinase-1, and inhibitor of kappaB-kinase-beta were measured by RT-PCR and Western blotting.

RESULTS:

The extract induced a significant reduction in reactive oxygen species generation, the expression of p47(phox), intranuclear nuclear factor-kappaB binding, and the expression of jun-N-terminal kinase-1, inhibitor of kappaB-kinase-beta, phosphotyrosine phosphatase-1B, and suppressor of cytokine signaling-3 in mononuclear cells when compared with the baseline and the placebo. PCE intake also suppressed plasma concentrations of TNF-alpha, IL-6, and C-reactive protein. There was no change in these indices in the control group given placebo.

CONCLUSIONS:

The PCE-containing resveratrol has a comprehensive suppressive effect on oxidative and inflammatory stress.

PMID:
20534755
PMCID:
PMC2936054
DOI:
10.1210/jc.2010-0482
[Indexed for MEDLINE]
Free PMC Article
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