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J Leukoc Biol. 2010 Nov;88(5):897-903. doi: 10.1189/jlb.0410188. Epub 2010 Jun 9.

FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.

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Institut de Médecine Moléculaire de Rangueil, Toulouse Cédex 4, France.


TNF-α is a pleiotropic cytokine involved in the regulation of various biological effects, including cell survival and proliferation, cell differentiation, and cell death. Moreover, TNF-α triggers proinflammatory responses, essentially through its ability to promote the expression of various proinflammatory genes. Most of the biological effects initiated by TNF-α rely on its ability to bind to and activate TNF-R1. As a consequence, molecular complexes are being formed, resulting from the recruitment of multiple adaptor proteins to the intracellular TNF-R1 DD. The adaptor protein FAN constitutively binds to a proximal membrane domain of TNF-R1 called NSD. Herein, the role of FAN in TNF-α-induced cell signaling and biological responses is discussed.

[Indexed for MEDLINE]

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