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PLoS One. 2010 Jun 3;5(6):e10943. doi: 10.1371/journal.pone.0010943.

Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model.

Author information

1
Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York, USA. netzerw@rockefeller.edu

Abstract

beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in younger individuals. We used a gamma-secretase inhibitor to lower beta-amyloid levels in young mice that model DS. This treatment corrected learning deficits characteristic of these mice, suggesting that beta-amyloid-lowering therapies might improve cognitive function in young DS patients.

PMID:
20532168
PMCID:
PMC2880593
DOI:
10.1371/journal.pone.0010943
[Indexed for MEDLINE]
Free PMC Article

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