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Lung India. 2009 Oct;26(4):106-8. doi: 10.4103/0970-2113.56342.

Five-year trend of acquired antitubercular drug resistance in patients attending a tertiary care hospital at Dehradun (Uttarakhand).

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1
Department of Pulmonary Medicine, Himalayan Institute of Medical Sciences, Swami Rama Nagar, Doiwala, Dehradun (Uttaranchal), India.

Abstract

BACKGROUND/AIM:

To study the prevalence and trend of acquired drug resistance to the first line antitubercular drugs.

MATERIALS AND METHODS:

Sputum of 215 previously treated adult pulmonary tuberculosis (TB) patients over a period of 2002-2006 were subjected to culture and sensitivity testing against common antitubercular drugs.

RESULT:

Growth of Mycobacterium tuberculosis was obtained from sputum specimen of 184 (85.58%) of the 215 patients who were studied; Overall, 113 (62.77%) of these were resistant to at least one antitubercular drug. Resistance to isoniazid was most common (62.22%) followed by rifampicin (57.22%). Multidrug resistance (MDR) was observed in 103 (57.22%) cases. During the five-year study period, an increasing trend in drug resistance including MDR-TB was observed.

CONCLUSION:

This study showed increasing trend in drug resistance including MDR-TB in five years.

KEYWORDS:

Acquired drug resistance; multi-drug resistance; tuberculosis

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