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Pediatr Emerg Care. 2010 Jun;26(6):448-54; quiz 455-7. doi: 10.1097/PEC.0b013e3181e15e36.

Occult pneumococcal bacteremia: a review.

Author information

1
Community Pediatric Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. joffe@email.chop.edu

Abstract

Occult bacteremia is primarily caused by Streptococcus pneumoniae and has been an intense clinical controversy in pediatric emergency medicine, with passionate opinions rendered from inside and outside the field. Vaccine development and widespread immunization have rapidly affected the changing epidemiology of this disease. There is a growing consensus that the reduction in incidence of occult bacteremia and the significant problem of antibiotic resistance are tipping the balance in favor of no testing and no treatment for well-appearing febrile children between 6 and 36 months of age who are immunized with Haemophilus influenzae B vaccination and PCV-7 (pneumococcal conjugate vaccine). This review of occult pneumococcal bacteremia will not only elaborate on current knowledge and clinical practice, but will also provide historical context to this fascinating phenomenon.

PMID:
20531134
DOI:
10.1097/PEC.0b013e3181e15e36
[Indexed for MEDLINE]

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