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Cancer Causes Control. 2010 Oct;21(10):1615-24. doi: 10.1007/s10552-010-9590-x. Epub 2010 Jun 6.

Hypertension, antihypertensive medication use, and breast cancer risk in the California Teachers Study cohort.

Author information

1
Department of Epidemiology, College of Health Sciences, University of California Irvine, Irvine, CA 92697-7555, USA. jlargent@uci.edu

Abstract

BACKGROUND:

We investigated the association between hypertension, antihypertensive (AH) medication use, and breast cancer in a large prospective study, the California Teachers Study (CTS).

METHODS:

Information on history of hypertension and lifetime regular use of AH medications was collected from 114,549 women in 1995-1996. Among them, 4,151 invasive breast cancers were diagnosed between 1995 and 2006. Additional information on AH use was collected from 73,742 women in 2000-2001, and 1,714 of these women were subsequently diagnosed with breast cancer. Cox proportional hazards regression was used to estimate relative risks (RR) and 95% confidence intervals (CI) for breast cancer.

RESULTS:

Use of AH medication for ≥5 years, when compared with no use, was associated with a modest increased risk of invasive breast cancer (RR = 1.18, 95%CI 1.02-1.36). This increased risk appeared to be confined to estrogen receptor (ER)-positive tumors (RR = 1.21, 95%CI 1.03-1.43) and pre-/peri-menopausal women (RR = 1.58, 95%CI 1.11-2.25).

CONCLUSIONS:

Increased risk of invasive breast cancer was observed for long-term (≥5 years) AH use, and this appeared to be confined to ER + breast cancer and younger women.

PMID:
20526803
PMCID:
PMC2941047
DOI:
10.1007/s10552-010-9590-x
[Indexed for MEDLINE]
Free PMC Article

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