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J Dent Res. 2010 Sep;89(9):933-7. doi: 10.1177/0022034510373763. Epub 2010 Jun 4.

A community-based RCT for oral cancer screening with toluidine blue.

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  • 1Division of Biostatistics, Graduate Institute of Epidemiology/Centre of Biostatistics Consultation, College of Public Health, National Taiwan University, Room 533, No. 17, Hsu-chow Road, Taipei, 100, Taiwan.

Abstract

Early detection of oral premalignant lesions (OPMLs) by visual inspection with toluidine blue has not been addressed. We conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of OPMLs and could further reduce the incidence of oral cancer. In 2000, in Keelung, we randomly assigned a total of 7975 individuals, aged 15 years or older and with high-risk oral habits, to either the toluidine-blue-screened (TBS) group or the visual screening group. Results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the TBS group than in the control group. After a five-year follow-up ascertaining oral cancer development through linkage to the National Cancer Registry, the incidence rate in the TBS group (28.0 x 10(-5)) was non-significantly 21% lower than that in the control group (35.4 x 10(-5)).

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