Format

Send to

Choose Destination
See comment in PubMed Commons below
J Exp Clin Cancer Res. 2010 Jun 4;29:64. doi: 10.1186/1756-9966-29-64.

Cytolytic T-cell response against Epstein-Barr virus in lung cancer patients and healthy subjects.

Author information

1
Cancer Immunology Unit, Department of Immunology & Histocompatibility, School of Medicine, University of Thessaly, University Hospital of Larissa, GR-411 10 Larissa, Greece. vkaran@med.uth.gr

Abstract

BACKGROUND:

This study aimed to examine whether EBV seropositive patients with lung cancer have an altered virus-specific CTL response, as compared to age-matched healthy controls and whether any variation in this response could be attributed to senescence.

METHODS:

Peripheral blood mononuclear cells from lung cancer patients, age-matched and younger healthy individuals were used to measure EBV-specific CTLs after in vitro amplification with the GLCTLVAML and RYSIFFDYM peptides followed by HLA-multimer staining.

RESULTS:

Lung cancer patients and aged-matched controls had significantly lesser EBV-specific CTL than younger healthy individuals. Multimer positive populations from either group did not differ with respect to the percentage of multimer positive CTLs and the intensity of multimer binding.

CONCLUSIONS:

This study provides evidence that patients with lung cancer exhibit an EBV-specific CTL response equivalent to that of age-matched healthy counterparts. These data warrant the examination of whether young individuals have a more robust anti-tumor response, as is the case with the anti-EBV response.

PMID:
20525347
PMCID:
PMC2907867
DOI:
10.1186/1756-9966-29-64
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for BioMed Central Icon for PubMed Central
    Loading ...
    Support Center