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Acta Pol Pharm. 2010 May-Jun;67(3):239-46.

Synthesis, characterization and antimicrobial evaluation of some new 1,3-thiazole-2,4-diamine derivatives.

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  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi 110062, India.


Various N,N'-diaryl-1,3-thiazole-2,4-diamines (3a-w) were synthesized by a three steps process. The structures of the synthesized compounds were confirmed by spectral data and elemental analyses. All the synthesized compounds were tested against two bacterial strains and two fungal strains. Bacterial strains included Gram positive Staphylococcus aureus and Gram negativeve Escherichia coli and fungal strains included Monascus purpurea and Penicillium citrinum. Most of the compounds showed moderate to good antibacterial as well as antifungal activity.

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