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Audiol Neurootol. 2011;16(1):36-40. doi: 10.1159/000315063. Epub 2010 Jun 3.

Extraintestinal Crohn's disease mimicking autoimmune inner ear disease: a histopathological approach.

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1
Institute of Surgical Pathology, University Hospital Zurich, Zurich, Switzerland. m.dettmer@gmx.net

Abstract

Patients with autoimmune inner ear disease develop rapidly progressive sensorineural hearing loss over a period of several weeks or months, often accompanied by vestibular loss. This disease can occur as a distinct clinical entity or in association with an underlying autoimmune disorder. Treatment comprises immunosuppression by corticosteroids, cytostatic drugs or tumor necrosis factor-α antagonists. We report histopathological and immunohistochemical findings of the inner ear of a patient with a granulomatous inner ear disease suffering from Crohn's disease that was nonresponsive to treatment and who underwent surgery for bilateral cochlear implants.

PMID:
20523038
DOI:
10.1159/000315063
[Indexed for MEDLINE]
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