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Fertil Steril. 2011 Jan;95(1):170-5. doi: 10.1016/j.fertnstert.2010.04.006. Epub 2010 Jun 1.

Correlation of ovarian reserve tests with histologically determined primordial follicle number.

Author information

1
Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA. karl-hansen@ouhsc.edu

Abstract

OBJECTIVE:

To investigate the relationship between clinical markers of ovarian reserve and the true ovarian reserve as determined by the ovarian primordial follicle number.

DESIGN:

Prospective investigation.

SETTING:

Academic medical center.

PATIENT(S):

Forty-two healthy women (aged 26-52 years) undergoing oophorectomy for benign gynecologic indications.

INTERVENTION(S):

Transvaginal ultrasound examination for the determination of the ovarian antral follicle count (AFC) and serum measurements of clinical markers of ovarian reserve. All measurements were obtained within 2 weeks of surgery, irrespective of cycle day. Ovarian primordial follicle count was then determined using a validated fractionator/optical disector method.

MAIN OUTCOME MEASURE(S):

Univariate and partial correlations between ovarian reserve markers and ovarian primordial follicle count.

RESULT(S):

There were significant correlations between the ovarian primordial follicle count and AFC (r=0.78), anti-Müllerian hormone (AMH; r=0.72), FSH (r=-0.32), inhibin B (r=0.40), and chronological age (r=-0.80). After adjusting for age, significant correlations were identified between the ovarian primordial follicle count and AFC (r=0.53) and AMH (r=0.48).

CONCLUSION(S):

The ovarian AFC and serum levels of AMH correlate with the ovarian primordial follicle number even after adjustment for chronological age.

[Indexed for MEDLINE]

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