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Platelets. 2010;21(5):368-72. doi: 10.3109/09537101003628421.

Coronary heart disease is associated with mean platelet volume in type 2 diabetic patients.

Author information

1
Gazi University, Faculty of Medicine, Department of Cardiology, Ankara, Turkey. yusuftavil@gmail.com

Abstract

BACKGROUND:

Mean platelet volume (MPV) is an indicator of platelet activation which is a central process in the pathophysiology of coronary heart disease (CHD). The aim of the study was twofold; first to determine whether MPV values is increased in patients with DM, and secondly to evaluate the relation between diabetic complications and MPV.

METHODS:

The study population included 258 patients divided into two groups. Group A composed of 158 type 2 diabetic patients with coexistent coronary artery disease (stenotic lesions of 50%) (78 women, 80 men; mean age 53.9_10.8; mean diabetes duration 13.1_6.0). One hundred subjects (48 women, 52 men; mean age 53.9_11) without type 2 diabetes with normal coronary angiographies were taken as the control group (group B). To evaluate the extension of CHD, Gensini scoring system was used.

RESULTS:

The MPV was significantly different in the patient group compared to the controls (9.79 +/- 1.5 fl vs 8.3 +/- 0.9 fl, P<0.001). The existence of CHD was associated with MPV with odds ratio (95% CI) of 2.31 (1.55-4.42, p50.001).

CONCLUSION:

We have found that diabetic patients with coronary heart disease have significantly higher MPV values compared to control subjects without diabetes and with angiographically normal coronary arteries.

PMID:
20521863
DOI:
10.3109/09537101003628421
[Indexed for MEDLINE]

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