Format

Send to

Choose Destination
J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):225-33. doi: 10.1007/s10911-010-9184-y. Epub 2010 Jun 4.

The pathology of EMT in mouse mammary tumorigenesis.

Author information

1
Center for Comparative Medicine, University of California, Davis, One Shields Ave, Davis, CA 95616, USA. rdcardiff@ucdavis.edu

Abstract

Epithelial-mesenchymal-transition (EMT) tumorigenesis in the mouse was first described over 100 years ago using various terms such as carcinosarcoma and without any comprehension of the underlying mechanisms. Such tumors have been considered artifacts of transplantation and of tissue culture. Recently, EMT tumors have been recognized in mammary glands of genetically engineered mice. This review provides a historical perspective leading to the current status in the context of some of the key molecular biology. The biology of mouse mammary EMT tumorigenesis is discussed with comparisons to human breast cancer.

PMID:
20521088
PMCID:
PMC2886116
DOI:
10.1007/s10911-010-9184-y
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center