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Nat Struct Mol Biol. 2010 Jun;17(6):650-2. doi: 10.1038/nsmb0610-650.

The quest to understand heterotrimeric G protein signaling.

Author information

1
Life Sciences Institute and the Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA. tesmerjj@umich.edu

Abstract

Over the past fifteen years, great strides have been made to understand how heterotrimeric G proteins control their downstream targets. However, the mechanism by which heterotrimeric G proteins are activated by their upstream G protein-coupled receptors (GPCRs) remains obscure. Recent structural data support the idea that GPCRs, despite their small size, are sophisticated allosteric machines with multiple signaling outputs.

PMID:
20520658
PMCID:
PMC2954486
DOI:
10.1038/nsmb0610-650
[Indexed for MEDLINE]
Free PMC Article

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