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Nat Struct Mol Biol. 2010 Jun;17(6):646-9. doi: 10.1038/nsmb0610-646.

Enhanced interrogation: emerging strategies for cell signaling inhibition.

Author information

1
Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

Abstract

Here we summarize recent and developing chemical approaches for modulating signaling pathways. In particular, we discuss targeting mutant signaling proteins, disrupting protein-protein interactions in cellular signaling networks, designing bivalent inhibitors of signaling proteins and identifying allosteric regulators of signaling enzymes. Over the past decade, great progress in the harvesting of chemical tools for basic research and clinical medicine has been made, but many challenges remain, and examples of exciting future targets are highlighted.

PMID:
20520657
PMCID:
PMC3160762
DOI:
10.1038/nsmb0610-646
[Indexed for MEDLINE]
Free PMC Article

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