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Leukemia. 2010 Jul;24(7):1249-57. doi: 10.1038/leu.2010.104. Epub 2010 Jun 3.

The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis.

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Department of Pathophysiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.


Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed.

[Indexed for MEDLINE]

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