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J Neurosci. 2010 Jun 2;30(22):7466-72. doi: 10.1523/JNEUROSCI.0859-10.2010.

Early stress is associated with alterations in the orbitofrontal cortex: a tensor-based morphometry investigation of brain structure and behavioral risk.

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1
Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin 53705, USA. jlhanson5@wisc.edu

Abstract

Individuals who experience early adversity, such as child maltreatment, are at heightened risk for a broad array of social and health difficulties. However, little is known about how this behavioral risk is instantiated in the brain. Here we examine a neurobiological contribution to individual differences in human behavior using methodology appropriate for use with pediatric populations paired with an in-depth measure of social behavior. We show that alterations in the orbitofrontal cortex among individuals who experienced physical abuse are related to social difficulties. These data suggest a biological mechanism linking early social learning to later behavioral outcomes.

PMID:
20519521
PMCID:
PMC2893146
DOI:
10.1523/JNEUROSCI.0859-10.2010
[Indexed for MEDLINE]
Free PMC Article
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