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Nucleic Acids Res. 2010 Jul;38(Web Server issue):W78-83. doi: 10.1093/nar/gkq482. Epub 2010 Jun 2.

R spider: a network-based analysis of gene lists by combining signaling and metabolic pathways from Reactome and KEGG databases.

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1
Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Institute for Bioinformatics and Systems Biology, Ingolstädter Landstrasse 1, D-85764 Neuherberg, Germany. alexey.antonov@helmholtz-muenchen.de

Abstract

R spider is a web-based tool for the analysis of a gene list using the systematic knowledge of core pathways and reactions in human biology accumulated in the Reactome and KEGG databases. R spider implements a network-based statistical framework, which provides a global understanding of gene relations in the supplied gene list, and fully exploits the Reactome and KEGG knowledge bases. R spider provides a user-friendly dialog-driven web interface for several model organisms and supports most available gene identifiers. R spider is freely available at http://mips.helmholtz-muenchen.de/proj/rspider.

PMID:
20519200
PMCID:
PMC2896180
DOI:
10.1093/nar/gkq482
[Indexed for MEDLINE]
Free PMC Article
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