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Eur J Prev Cardiol. 2012 Feb;19(1):23-31. doi: 10.1097/HJR.0b013e32833b0932. Epub 2011 Jan 28.

HbA1c is an independent predictor of non-fatal cardiovascular disease in a Caucasian population without diabetes: a 10-year follow-up of the Hoorn Study.

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1
EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. e.vantriet@vumc.nl

Abstract

AIMS:

To investigate the associations of HbA1c, fasting glucose, and postload plasma glucose with 10-year fatal and non-fatal cardiovascular disease (CVD) and all-cause mortality in Caucasian individuals between 50 and 75 years of age without diabetes.

METHOD AND RESULTS:

The 10-year risk of all-cause mortality and CVD in relation to HbA1cand glucose levels was assessed with Cox survival analysis in 1674 non-diabetic individuals of a population-based cohort (Hoorn Study). Analyses were stratified according to sex and adjustments were made for age and known CVD risk factors. After full adjustment, HbA1c levels ≥ 6.0% were significantly associated with an increased risk of non-fatal CVD compared with the lowest category of HbA1c (≤ 5.1%) in women [hazards ratio (HR) 2.27 (1.24-4.14)]. In addition, HbA1c as a continuous variable was significantly related to non-fatal CVD in both men [HR 1.40 (1.01-1.95)] and women [HR 2.41 (1.51-3.83)]. The relationships of HbA1 c with fatal CVD and all-cause mortality were explained by traditional CVD risk factors in both the sexes, along with the associations between fasting or postload plasma glucose and any of the outcome measures.

CONCLUSION:

In Caucasian men and especially in women between 50 and 75 years of age who are without diabetes, high HbA1c levels are associated with increased risk of future non-fatal CVD, independent of other CVD risk factors.

PMID:
20517157
DOI:
10.1097/HJR.0b013e32833b0932
[Indexed for MEDLINE]
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