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Med Princ Pract. 2010;19(4):255-9. doi: 10.1159/000312710. Epub 2010 May 26.

In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits.

Author information

1
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia.

Abstract

OBJECTIVE:

To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models.

METHODS:

The analgesic effect was evaluated using acetic acid-induced writhing, hot plate and formalin tests.

RESULTS:

The extract (60-600 mg/kg) significantly (p < 0.05) inhibited the writhing test in a dose-dependent manner with the percentage of analgesia recorded between 51.8 and 74.1%. In addition, the extract also significantly (p < 0.05) increased the latency time in the hot plate test in a dose-dependent manner. Further study showed that the extract elicited inhibitory activity in both the early and late phases of the formalin test. Moreover, pretreatment with 5 mg/kg naloxone, a nonselective opioid receptor antagonist, significantly (p < 0.05) modified the antinociceptive effect of the extract in all tests.

CONCLUSION:

The aqueous extract of T. indica possesses potential antinociceptive activity at both the peripheral and central levels, which are mediated via activation of the opioidergic mechanism.

PMID:
20516700
DOI:
10.1159/000312710
[Indexed for MEDLINE]
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