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HFSP J. 2009 Dec;3(6):373-8. doi: 10.2976/1.3249971. Epub 2009 Nov 12.

How are nucleosomes disrupted during transcription elongation?

Abstract

Chromatin structure is a powerful tool to regulate eukaryotic transcription. Moreover, nucleosomes are constantly remodeled, disassembled, and reassembled in the body of transcribed genes. Here we propose a general model that explains, in quantitative terms, how transcription elongation affects nucleosome structure at a distance as a result of the positive torque the polymerases create as they translocate along DNA templates.

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