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J Bone Joint Surg Br. 2010 Jun;92(6):760-2. doi: 10.1302/0301-620X.92B6.23788.

Photodynamic therapy with acridine orange in musculoskeletal sarcomas.

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Department of Orthopaedic Surgery Mie University Graduate School of Medicine, Edobashi 2-174 Tsu City, Japan.


Limb salvage involving wide resection and reconstruction is now well established for managing musculoskeletal sarcomas. However, involvement of major nerves and vessels with a large volume of muscle and skin may result in a useless limb, contributing to depression and a low quality of life. We have been studying alternative treatments for musculoskeletal sarcoma since 1990, and have recently established a regime using photodynamic surgery with cells labelled with acridine orange, photodynamic therapy with cells treated similarly and radiodynamic treatment using the effect of X-rays on such cells. These techniques have been used after marginal or intralesional resection of tumours since 1999 and have enabled maintenance of excellent limb function in patients with sarcomas.

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