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J Bone Joint Surg Br. 2010 Jun;92(6):760-2. doi: 10.1302/0301-620X.92B6.23788.

Photodynamic therapy with acridine orange in musculoskeletal sarcomas.

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1
Department of Orthopaedic Surgery Mie University Graduate School of Medicine, Edobashi 2-174 Tsu City, Japan.

Abstract

Limb salvage involving wide resection and reconstruction is now well established for managing musculoskeletal sarcomas. However, involvement of major nerves and vessels with a large volume of muscle and skin may result in a useless limb, contributing to depression and a low quality of life. We have been studying alternative treatments for musculoskeletal sarcoma since 1990, and have recently established a regime using photodynamic surgery with cells labelled with acridine orange, photodynamic therapy with cells treated similarly and radiodynamic treatment using the effect of X-rays on such cells. These techniques have been used after marginal or intralesional resection of tumours since 1999 and have enabled maintenance of excellent limb function in patients with sarcomas.

PMID:
20513869
DOI:
10.1302/0301-620X.92B6.23788
[Indexed for MEDLINE]
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