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Clin Lab Med. 2010 Mar;30(1):237-60. doi: 10.1016/j.cll.2010.01.001.

Yellow fever: a reemerging threat.

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1
Center for Vaccine Research, Department of Microbiology and Molecular Genetics, University of Pittsburgh, PA 15261, USA.

Abstract

Yellow fever (YF) is a viral disease, endemic to tropical regions of Africa and the Americas, which principally affects humans and nonhuman primates and is transmitted via the bite of infected mosquitoes. Yellow fever virus (YFV) can cause devastating epidemics of potentially fatal, hemorrhagic disease. Despite mass vaccination campaigns to prevent and control these outbreaks, the risk of major YF epidemics, especially in densely populated, poor urban settings, both in Africa and South America, has greatly increased. Consequently, YF is considered an emerging, or reemerging disease of considerable importance. This article comprehensively reviews the history, microbiology, epidemiology, clinical presentation, diagnosis, and treatment of YFV, as well as the vaccines produced to combat YF.

PMID:
20513550
PMCID:
PMC4349381
DOI:
10.1016/j.cll.2010.01.001
[Indexed for MEDLINE]
Free PMC Article
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