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Mol Cell. 2010 May 28;38(4):481-2. doi: 10.1016/j.molcel.2010.05.008.

A metabolic (re-)balancing act.

Author information

1
Center for Integrative Biology and Biotherapeutics, Pfizer Biopharmaceuticals, Pearl River, NY 10965, USA. robert.abraham@pfizer.com

Abstract

Cells lacking a functional tuberous sclerosis complex (TSC) heterodimer are sensitized to glucose starvation-induced death. In this issue of Molecular Cell, Choo et al. (2010) report that reducing energy consumption allows these cells to survive on glutamine as an alternative energy source.

PMID:
20513422
DOI:
10.1016/j.molcel.2010.05.008
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