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Nat Neurosci. 2010 Jul;13(7):819-21. doi: 10.1038/nn.2563. Epub 2010 May 30.

Fragile X mental retardation protein controls gating of the sodium-activated potassium channel Slack.

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1
Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA.

Abstract

In humans, the absence of Fragile X mental retardation protein (FMRP), an RNA-binding protein, results in Fragile X syndrome, the most common inherited form of intellectual disability. Using biochemical and electrophysiological studies, we found that FMRP binds to the C terminus of the Slack sodium-activated potassium channel to activate the channel in mice. Our findings suggest that Slack activity provides a link between patterns of neuronal firing and changes in protein translation.

PMID:
20512134
PMCID:
PMC2893252
DOI:
10.1038/nn.2563
[Indexed for MEDLINE]
Free PMC Article
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