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J Vis Exp. 2010 May 26;(39). pii: 1730. doi: 10.3791/1730.

Programmed electrical stimulation in mice.

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1
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, USA.

Abstract

Genetically-modified mice have emerged as a preferable animal model to study the molecular mechanisms underlying conduction abnormalities, atrial and ventricular arrhythmias, and sudden cardiac death.(1) Intracardiac pacing studies can be performed in mice using a 1.1F octapolar catheter inserted into the jugular vein, and advanced into the right atrium and ventricle. Here, we illustrate the steps involved in performing programmed electrical stimulation in mice. Surface ECG and intracardiac electrograms are recorded simultaneously in the atria, atrioventricular junction, and ventricular myocardium, whereas intracardiac pacing of the atrium is performed using an external stimulator. Thus, programmed electrical stimulation in mice provides unique opportunities to explore molecular mechanisms underlying conduction defects and cardiac arrhythmias.

PMID:
20512106
PMCID:
PMC3152855
DOI:
10.3791/1730
[Indexed for MEDLINE]
Free PMC Article
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