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Cell. 2010 May 28;141(5):752-4. doi: 10.1016/j.cell.2010.05.010.

A bone to pick with compulsive behavior.

Author information

  • 1Department of Neurobiology, Harvard Medical School, Massachusetts Hall, Cambridge, MA 02138, USA. seh@harvard.edu

Abstract

Mice with mutations in the Hoxb8 gene exhibit compulsive grooming behavior. Chen et al. (2010) now report that this behavior stems from Hoxb8 deficiency in microglia, a type of immune cell in the brain derived from bone marrow. These findings provide intriguing connections between immune dysfunction and neuropsychiatric disorders.

PMID:
20510922
DOI:
10.1016/j.cell.2010.05.010
[PubMed]
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