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Cell. 2010 May 28;141(5):739-45. doi: 10.1016/j.cell.2010.05.019.

Quantitative genetic interactions reveal biological modularity.

Author information

1
Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, CA 94158, USA.

Abstract

Traditionally, research has been reductionist, characterizing the individual components of biological systems. But new technologies have increased the size and scope of biological data, and systems approaches have broadened the view of how these components are interconnected. Here, we discuss how quantitative mapping of genetic interactions enhances our view of biological systems, allowing their deeper interrogation across different biological scales.

PMID:
20510918
PMCID:
PMC2946632
DOI:
10.1016/j.cell.2010.05.019
[Indexed for MEDLINE]
Free PMC Article

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