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Immunity. 2010 May 28;32(5):587-90. doi: 10.1016/j.immuni.2010.04.015.

Special delivery for MHC II via autophagy.

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1
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA.

Abstract

In this issue of Immunity, Blanchet et al. (2010) report that human immunodeficiency virus-1 inhibits macroautophagy in dendritic cells, attenuating MHC II presentation. Lee et al. (2010) previously revealed the requirement of autophagic machinery for MHC II presentation of herpes viral antigens.

PMID:
20510868
DOI:
10.1016/j.immuni.2010.04.015
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