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Neuron. 2010 May 27;66(4):473-5. doi: 10.1016/j.neuron.2010.05.016.

Ménage à Trio during BMP-Mediated Retrograde Signaling at the NMJ.

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Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.


In flies, retrograde BMP signaling is an important mechanism by which postsynaptic cells regulate the structure and function of presynaptic terminals, ostensibly through changes in gene expression. Transcriptional targets, however, have remained mysterious. In this issue of Neuron, Haghighi and colleagues begin to unravel this puzzle by identifying the cytoskeletal regulator Trio.

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