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Bioorg Med Chem. 2010 Jun 15;18(12):4255-68. doi: 10.1016/j.bmc.2010.04.092. Epub 2010 May 24.

Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.

Author information

1
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China.

Abstract

A novel class of non-steroidal progesterone receptor antagonists with aromatic beta-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. Among them, compound 22 was shown to be the most potent progesterone receptor antagonist in cotransfection assay and a murine model of ligand-induced decidualization.

PMID:
20510622
DOI:
10.1016/j.bmc.2010.04.092
[Indexed for MEDLINE]

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