[Spectrophotometric and HPLC evaluation of ceftazidime stability]

Rev Med Chir Soc Med Nat Iasi. 2010 Jan-Mar;114(1):260-5.
[Article in Romanian]

Abstract

In this paper we followed up the stability of ceftazidime, raw material used in drug industry. Matherials and methods: We used three spectrophotometric methods based on ceftazidime property to form complexes with p-chloranilic acid (ac. p-CA), 3-methylbenzothiazolin-2-on hydrazone (MBTH) and N-(1-naphtil) etilendiamine (NEDA) and a chromatographic method (HPLC).

Results: Our results revealed that the substances analyzed maintained minimum content allowable.

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Benzoquinones / chemistry
  • Benzothiazoles / chemistry
  • Ceftazidime / chemistry*
  • Chromatography, High Pressure Liquid* / methods
  • Drug Stability
  • Hydrazones / chemistry
  • Spectrophotometry* / methods

Substances

  • Anti-Bacterial Agents
  • Benzoquinones
  • Benzothiazoles
  • Hydrazones
  • Ceftazidime
  • 3-methyl-2-benzothiazolone hydrazone
  • chloranilic acid