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EMBO Rep. 2010 Jul;11(7):541-7. doi: 10.1038/embor.2010.75. Epub 2010 May 28.

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes.

Author information

1
Department of Functional Genomics, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Parc d'Innovation, 1 rue Laurent Fries, CNRS UMR 7104, INSERM U 964, Université de Strasbourg, BP 10142, Illkirch Cedex 67404, France.

Abstract

The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes.

PMID:
20508642
PMCID:
PMC2897115
DOI:
10.1038/embor.2010.75
[Indexed for MEDLINE]
Free PMC Article

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