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Mol Cell Proteomics. 2010 Aug;9(8):1689-702. doi: 10.1074/mcp.R110.000067. Epub 2010 May 27.

Integrative structure modeling of macromolecular assemblies from proteomics data.

Author information

1
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA. kerenl@salilab.org

Abstract

Proteomics techniques have been used to generate comprehensive lists of protein interactions in a number of species. However, relatively little is known about how these interactions result in functional multiprotein complexes. This gap can be bridged by combining data from proteomics experiments with data from established structure determination techniques. Correspondingly, integrative computational methods are being developed to provide descriptions of protein complexes at varying levels of accuracy and resolution, ranging from complex compositions to detailed atomic structures.

PMID:
20507923
PMCID:
PMC2938050
DOI:
10.1074/mcp.R110.000067
[Indexed for MEDLINE]
Free PMC Article
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